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1

Sesamin, a sesame lignan, is a potent inducer of hepatic fatty acid oxidation in the rat

Lakshmikuttyamma Ashakumary, Isabelle Rouyer, Yoko Takahashi, Takashi Ide, Nobuhiro Fukuda, Toshifumi Aoyama, Takashi Hashimoto, Michinao Mizugaki, Michihiro Sugano

Journal:

Year:

1999

Language:

english

File:

PDF, 2.62 MB

english, 1999

2

Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s

David J. Waxman, David P. Lapenson, Toshifumi Aoyama, Harry V. Gelboin, Frank J. Gonzalez, Ken Korzekwa

Journal:

Archives of Biochemistry and Biophysics

Year:

1991

Language:

english

File:

PDF, 1.19 MB

english, 1991

3

Purification and Identification of Antihypertensive Peptides from Fermented Buckwheat Sprouts

Koyama, Masahiro, Naramoto, Kyoko, Nakajima, Takero, Aoyama, Toshifumi, Watanabe, Masanori, Nakamura, Kozo

Journal:

Journal of Agricultural and Food Chemistry

Year:

2013

Language:

english

File:

PDF, 1.34 MB

english, 2013

4

Development of automatic weld bead finishing system using plasma arc gouging

Hamada, Takashi, Kato, Tsuyoshi, Aoyama, Kazuo, Aikawa, Tetsuro, Asai, Satoru, Kurokawa, Toshifumi, Takebayashi, Hiroyuki

Journal:

Welding in the World

Year:

2014

Language:

english

File:

PDF, 3.62 MB

english, 2014

5

PPARα-dependent cholesterol/testosterone disruption in Leydig cells mediates 2,4-dichlorophenoxyacetic acid-induced testicular toxicity in mice

Harada, Yukiko, Tanaka, Naoki, Ichikawa, Motoki, Kamijo, Yuji, Sugiyama, Eiko, Gonzalez, Frank J., Aoyama, Toshifumi

Journal:

Archives of Toxicology

Year:

2016

Language:

english

File:

PDF, 4.64 MB

english, 2016

6

The role of meteoric water recharge in stimulating biogenic methane generation: A case study from the Tempoku Coal Field, Japan

Tamamura, Shuji, Murakami, Takuma, Aramaki, Noritaka, Ueno, Akio, Tamazawa, Satoshi, Badrul, Alam A.K.M., Haq, Shofa Rijalul, Igarashi, Toshifumi, Aoyama, Hideo, Yamaguchi, Shinji, Kaneko, Katsuhiko

Journal:

International Journal of Coal Geology

Year:

2018

Language:

english

File:

PDF, 5.45 MB

english, 2018

7

Molecular basis of very long chain acyl-CoA dehydrogenase deficiency in three Israeli patients: Identification of a complex mutant allele with P65L and K247Q mutations, the former being an exonic mutation causing exon 3 skipping

Hiroh Watanabe, Kenji E. Orii, Toshiyuki Fukao, Xiang-Qian Song, Toshifumi Aoyama, Lodewijk IJlst, Jos Ruiter, Ronald J.A. Wanders, Naomi Kondo

Journal:

Year:

2000

Language:

english

File:

PDF, 343 KB

english, 2000

8

Peroxisome proliferator-activated receptor α protects against alcohol-induced liver damage

Tamie Nakajima, Yuji Kamijo, Naoki Tanaka, Eiko Sugiyama, Eiji Tanaka, Kendo Kiyosawa, Yoshimitsu Fukushima, Jeffrey M. Peters, Frank J. Gonzalez, Toshifumi Aoyama

Journal:

Year:

2004

Language:

english

File:

PDF, 1.06 MB

english, 2004

9

Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor α in transgenic mice: Implications for HCV-associated hepatocarcinogenesis

Naoki Tanaka, Kyoji Moriya, Kendo Kiyosawa, Kazuhiko Koike, Toshifumi Aoyama

Journal:

International Journal of Cancer

Year:

2008

Language:

english

File:

PDF, 493 KB

english, 2008

10

Mutagen activation by cDNA-expressed P1450, P3450, and P450a

Toshifumi Aoyama, Frank J. Gonzalez, Harry V. Gelboin

Journal:

Molecular Carcinogenesis

Year:

1989

Language:

english

File:

PDF, 648 KB

english, 1989

11

Human cDNA-Expressed Cytochrome P450 IA2: Mutagen Activation and Substrate Specificity

Toshifumi Aoyama, Frank J. Gonzalez, Harry V. Gelboin

Journal:

Molecular Carcinogenesis

Year:

1989

Language:

english

File:

PDF, 615 KB

english, 1989

12

Stable expression of human cytochrome P450IA2 cDNA in a human lymphoblastoid cell line: Role of the enzyme in the metabolic activation of aflatoxin B1

Charles L. Crespi, Dorothy T. Steimel, Toshifumi Aoyama, Harry V. Gelboin, Frank J. Gonzalez

Journal:

Molecular Carcinogenesis

Year:

1990

Language:

english

File:

PDF, 367 KB

english, 1990

13

High pressure liquid chromatography methods for separation of ω- and (ω-1)-hydroxy fatty acids: Their applications to microsomal fatty acid ω-oxidation

Toshifumi Aoyama, Ryo Sato

Journal:

Analytical Biochemistry

Year:

1988

Language:

english

File:

PDF, 839 KB

english, 1988

14

Cholesterol/triglyceride-lowering effect of bezafibrate is independent of peroxisome proliferator-activated receptor activation in mice

Takero Nakajima, Xiaowei Zhang, Naoki Tanaka, Toshifumi Aoyama

Journal:

Chemistry and Physics of Lipids

Year:

2008

Language:

english

File:

PDF, 50 KB

english, 2008

15

Establishment of a quantitative, qualitative, and high-throughput analysis of sulfatides from small amounts of sera by matrix-assisted laser desorption ionization–time of flight mass spectrometry

Gang Li, Rui Hu, Yuji Kamijo, Takero Nakajima, Toshifumi Aoyama, Teruo Inoue, Koichi Node, Reiji Kannagi, Mamoru Kyogashima, Atsushi Hara

Journal:

Analytical Biochemistry

Year:

2007

Language:

english

File:

PDF, 358 KB

english, 2007

16

Molecular mechanism of age-specific hepatic lipid accumulation in PPARα (+/−): LDLR (+/−) mice, an obese mouse model

Eiko Sugiyama-Yokoyama, Yufeng Li, Shin Yokoyama, Naoki Tanaka, Toshifumi Aoyama

Journal:

Chemistry and Physics of Lipids

Year:

2008

Language:

english

File:

PDF, 51 KB

english, 2008

17

Eicosapentaenoic acid lowers plasma and liver cholesterol levels in the presence of peroxisome proliferator-activated receptor alpha

Eiko Sugiyama, Yufeng Li, Tomoko Ishikawa, Naoki Tanaka, Yuji Kamijo, Shin Yokoyama, Atsushi Hara, Toshifumi Aoyama

Journal:

Chemistry and Physics of Lipids

Year:

2009

Language:

english

File:

PDF, 45 KB

english, 2009

18

Multiple roles of PPARalpha in brown adipose tissue under constitutive and cold conditions

Eiko Sugiyama-Yokoyama, Shin Yokoyama, Takero Nakajima, Yuji Kamijo, Atsushi Hara, Toshifumi Aoyama

Journal:

Chemistry and Physics of Lipids

Year:

2010

Language:

english

File:

PDF, 214 KB

english, 2010

19

Molecular mechanics and molecular orbital simulations on specific interactions between peroxisome proliferator-activated receptor PPARα and plasticizer

Tomohiko Nakagawa, Noriyuki Kurita, Shinsaku Kozakai, Shingo Iwabuchi, Yoko Yamaguchi, Masato Hayakawa, Yuki Ito, Toshifumi Aoyama, Tamie Nakajima

Journal:

Journal of Molecular Graphics and Modelling

Year:

2008

Language:

english

File:

PDF, 2.57 MB

english, 2008

20

Microgram-order ammonium perfluorooctanoate may activate mouse peroxisome proliferator-activated receptor α, but not human PPARα

Toshiki Nakamura, Yuki Ito, Yukie Yanagiba, Doni Hikmat Ramdhan, Yasuhide Kono, Hisao Naito, Yumi Hayashi, Yufei Li, Toshifumi Aoyama, Frank J. Gonzalez, Tamie Nakajima

Journal:

Year:

2009

Language:

english

File:

PDF, 1.20 MB

english, 2009

21

Evaluation of transcatheter arterial embolization with epirubicin-lipiodol emulsion for hepatocellular carcinoma

Keiichi Aoyama, Takashi Tsukishiro, Kazuhiro Okada, Toshihiro Tsuchida, Nobuyasu Aiba, Shuji Nambu, Chiharu Miyabayashi, Toshifumi Yasuyama, Kiyohiro Higuchi, Akiharu Watanabe

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1992

Language:

english

File:

PDF, 344 KB

english, 1992

22

Induction of peroxisome proliferator-activated receptor alpha (PPARα)-related enzymes by di(2-ethylhexyl) phthalate (DEHP) treatment in mice and rats, but not marmosets

Yuki Ito, Osamu Yamanoshita, Yoshimasa Kurata, Michihiro Kamijima, Toshifumi Aoyama, Tamie Nakajima

Journal:

Archives of Toxicology

Year:

2007

Language:

english

File:

PDF, 184 KB

english, 2007

23

Modulation of ammonium perfluorooctanoate-induced hepatic damage by genetically different PPARα in mice

Tomohiko Nakagawa, Doni Hikmat Ramdhan, Naoki Tanaka, Hisao Naito, Hazuki Tamada, Yuki Ito, Yufei Li, Yumi Hayashi, Nozomi Yamagishi, Yukie Yanagiba, Toshifumi Aoyama, Frank J. Gonzalez, Tamie Nakajim

Journal:

Archives of Toxicology

Year:

2012

Language:

english

File:

PDF, 830 KB

english, 2012

24

Molecular characterization of the mouse very-long-chain acyl-CoA dehydrogenase gene

Koji O. Orii, Toshifumi Aoyama, Fumiko Saito-Ohara, Tatsuro Ikeuchi, Tadao Orii, Naomi Kondo, Takashi Hashimoto

Journal:

Mammalian Genome

Year:

1997

Language:

english

File:

PDF, 950 KB

english, 1997

25

Efficacy and safety of addition of minor bloodletting (petit phlebotomy) in hepatitis C virus-infected patients receiving regular glycyrrhizin injections

Naoki Tanaka, Akira Horiuchi, Takahiro Yamaura, Michiharu Komatsu, Takahide Yokoyama, Shinji Okaniwa, Tadanobu Nagaya, Kaname Yoshizawa, Kendo Kiyosawa, Toshifumi Aoyama, Eiji Tanaka

Journal:

Journal of Gastroenterology

Year:

2009

Language:

english

File:

PDF, 175 KB

english, 2009

26

Clinical characteristics of de novo nonalcoholic fatty liver disease following pancreaticoduodenectomy

Naoki Tanaka, Akira Horiuchi, Takahide Yokoyama, Gengo Kaneko, Naoto Horigome, Takahiro Yamaura, Tadanobu Nagaya, Michiharu Komatsu, Kenji Sano, Shin-ichi Miyagawa, Toshifumi Aoyama, Eiji Tanaka

Journal:

Journal of Gastroenterology

Year:

2011

Language:

english

File:

PDF, 612 KB

english, 2011

27

Serum sulfatides as a novel biomarker for cardiovascular disease in patients with end-stage renal failure

Rui Hu, Gang Li, Yuji Kamijo, Toshifumi Aoyama, Takero Nakajima, Teruo Inoue, Koichi Node, Reiji Kannagi, Mamoru Kyogashima, Atsushi Hara

Journal:

Glycoconjugate Journal

Year:

2007

Language:

english

File:

PDF, 218 KB

english, 2007

28

Kidney transplantation recovers the reduction level of serum sulfatide in ESRD patients via processes correlated to oxidative stress and platelet count

Lixuan Wang, Yuji Kamijo, Akihiro Matsumoto, Takero Nakajima, Makoto Higuchi, Reiji Kannagi, Mamoru Kyogashima, Toshifumi Aoyama, Atsushi Hara

Journal:

Glycoconjugate Journal

Year:

2011

Language:

english

File:

PDF, 446 KB

english, 2011

29

Systematic analyses of free ceramide species and ceramide species comprising neutral glycosphingolipids by MALDI-TOF MS with high-energy CID

Kouji Tanaka, Masaki Yamada, Keiko Tamiya-Koizumi, Reiji Kannagi, Toshifumi Aoyama, Atsushi Hara, Mamoru Kyogashima

Journal:

Glycoconjugate Journal

Year:

2011

Language:

english

File:

PDF, 1.40 MB

english, 2011

30

Molecular Mechanism of Age-Specific Hepatic Lipid Accumulation in PPARα (+/−):LDLR (+/−) Mice, an Obese Mouse Model

Yufeng Li, Eiko Sugiyama, Shin Yokoyama, Lingling Jiang, Naoki Tanaka, Toshifumi Aoyama

Journal:

Year:

2008

Language:

english

File:

PDF, 537 KB

english, 2008

31

Development from simple steatosis to liver cirrhosis and hepatocellular carcinoma: a 27-year follow-up case

Tadanobu Nagaya, Naoki Tanaka, Michiharu Komatsu, Tetsuya Ichijo, Kenji Sano, Akira Horiuchi, Satoru Joshita, Takeji Umemura, Akihiro Matsumoto, Kaname Yoshizawa, Toshifumi Aoyama, Kendo Kiyosawa, Eij

Journal:

Clinical Journal of Gastroenterology

Year:

2008

Language:

english

File:

PDF, 436 KB

english, 2008

32

PPARalpha protects against glomerulonephritis induced by long-term exposure to the plasticizer di-(2-ethylhexyl)phthalate

Yuji Kamijo, Toshifumi Aoyama

Journal:

Chemistry and Physics of Lipids

Year:

2007

Language:

english

File:

PDF, 54 KB

english, 2007

33

Serum cytokeratin 18 levels are useful biomarkers for estimating the histological activity score of nonalcoholic fatty liver disease

Toshifumi Aoyama, Naoki Tanaka

Journal:

Chemistry and Physics of Lipids

Year:

2009

Language:

english

File:

PDF, 53 KB

english, 2009

34

Multiple roles of PPARα in brown adipose tissue under constitutive and cold conditions

Makiko Komatsu, Yuhong Tong, Yufeng Li, Takero Nakajima, Gang Li, Rui Hu, Eiko Sugiyama, Yuji Kamijo, Naoki Tanaka, Atsushi Hara, Toshifumi Aoyama

Journal:

Year:

2010

Language:

english

File:

PDF, 536 KB

english, 2010

35

Role of metallothionein in Helicobacter pylori-positive gastric mucosa with or without early gastric cancer and the effect on its expression after eradication therapy

Toshifumi Mitani, Daisuke Shirasaka, Nobuo Aoyama, Ikuya Miki, Yoshinori Morita, Nobunao Ikehara, Yuko Matsumoto, Tatsuya Okuno, Masanori Toyoda, Hideyuki Miyachi, Shiei Yoshida, Naoko Chayahara, Junk

Journal:

Journal of Gastroenterology and Hepatology

Year:

2008

Language:

english

File:

PDF, 305 KB

english, 2008

36

Kidney dysfunction induced by protein overload nephropathy reduces serum sulfatide levels in mice

GANG LI, RUI HU, YUJI KAMIJO, TAKERO NAKAJIMA, TOSHIFUMI AOYAMA, TAKASHI EHARA, HIDEKAZU SHIGEMATSU, REIJI KANNAGI, MAMORU KYOGASHIMA, ATSUSHI HARA

Journal:

Year:

2009

Language:

english

File:

PDF, 266 KB

english, 2009

37

Insulin resistance and hepatitis C virus: a case–control study of non-obese, non-alcoholic and non-steatotic hepatitis virus carriers with persistently normal serum aminotransferase

Naoki Tanaka, Tadanobu Nagaya, Michiharu Komatsu, Akira Horiuchi, Goro Tsuruta, Haruaki Shirakawa, Takeji Umemura, Tetsuya Ichijo, Akihiro Matsumoto, Kaname Yoshizawa, Toshifumi Aoyama, Kendo Kiyosawa

Journal:

Liver International

Year:

2008

Language:

english

File:

PDF, 127 KB

english, 2008

38

Lidocaine metabolism in human liver microsomes by cytochrome P450IIIA4

Bargetzi, Mario J, Aoyama, Toshifumi, Gonzalez, Frank J, Meyer, Urs A

Journal:

Clinical Pharmacology & Therapeutics

Year:

1989

Language:

english

File:

PDF, 560 KB

english, 1989

39

Primary Levofloxacin Resistance and gyrA/B Mutations Among Helicobacter pylori in Japan

Hideyuki Miyachi, Ikuya Miki, Nobuo Aoyama, Daisuke Shirasaka, Yuko Matsumoto, Masanori Toyoda, Toshifumi Mitani, Yoshinori Morita, Takao Tamura, Shohiro Kinoshita, Yoshie Okano, Shunichi Kumagai, Mas

Journal:

Year:

2006

Language:

english

File:

PDF, 132 KB

english, 2006

40

Impact of Helicobacter pylori Eradication Therapy on Histologic Change in the Distal Esophagus

Masanori Toyoda, Daisuke Shirasaka, Nobuo Aoyama, Yoshinori Watanabe, Ikuya Miki, Yoshinori Morita, Yuko Matsumoto, Toshifumi Mitani, Hideyuki Miyachi, Takao Tamura, Masato Kasuga

Journal:

Year:

2006

Language:

english

File:

PDF, 291 KB

english, 2006

41

Cholesterol-lowering effect of bezafibrate is independent of peroxisome proliferator-activated receptor activation in mice

Takero Nakajima, Naoki Tanaka, Eiko Sugiyama, Yuji Kamijo, Atsushi Hara, Rui Hu, Gang Li, Yufeng Li, Kozo Nakamura, Frank J. Gonzalez, Toshifumi Aoyama

Journal:

Biochemical Pharmacology

Year:

2008

Language:

english

File:

PDF, 1.18 MB

english, 2008

42

Eicosapentaenoic acid improves hepatic steatosis independent of PPARα activation through inhibition of SREBP-1 maturation in mice

Naoki Tanaka, Xiuguo Zhang, Eiko Sugiyama, Hiroyuki Kono, Akira Horiuchi, Takero Nakajima, Hiroki Kanbe, Eiji Tanaka, Frank J. Gonzalez, Toshifumi Aoyama

Journal:

Biochemical Pharmacology

Year:

2010

Language:

english

File:

PDF, 1.30 MB

english, 2010

43

Two mechanistically distinct effects of dihydropyridine nifedipine on CaV1.2 L-type Ca2+ channels revealed by Timothy syndrome mutation

Xiaona Sheng, Tsutomu Nakada, Motohiro Kobayashi, Toshihide Kashihara, Toshihide Shibazaki, Miwa Horiuchi-Hirose, Simmon Gomi, Masamichi Hirose, Toshifumi Aoyama, Mitsuhiko Yamada

Journal:

European Journal of Pharmacology

Year:

2012

Language:

english

File:

PDF, 1.02 MB

english, 2012

44

Molecular mechanism of trichloroethylene-induced hepatotoxicity mediated by CYP2E1

Doni Hikmat Ramdhan, Michihiro Kamijima, Naoyasu Yamada, Yuki Ito, Yukie Yanagiba, Daichi Nakamura, Ai Okamura, Gaku Ichihara, Toshifumi Aoyama, Frank J. Gonzalez, Tamie Nakajima

Journal:

Toxicology and Applied Pharmacology

Year:

2008

Language:

english

File:

PDF, 1.10 MB

english, 2008

45

Pretreatment by low-dose fibrates protects against acute free fatty acid-induced renal tubule toxicity by counteracting PPARα deterioration

Kyoko Takahashi, Yuji Kamijo, Kazuhiko Hora, Koji Hashimoto, Makoto Higuchi, Takero Nakajima, Takashi Ehara, Hidekazu Shigematsu, Frank J. Gonzalez, Toshifumi Aoyama

Journal:

Toxicology and Applied Pharmacology

Year:

2011

Language:

english

File:

PDF, 2.56 MB

english, 2011

46

Relationship between structure and substrate-chain-length specificity of mitochondrial very-long-chain acyl-coenzyme A dehydrogenase

Masayoshi Souri, Toshifumi Aoyama, Seiji Yamaguchi, Takashi Hashimoto

Journal:

Year:

1998

Language:

english

File:

PDF, 334 KB

english, 1998

47

cDNA-directed expression of rat testosterone 7α-hydroxylase using the modified vaccinia virus, T7-RNA-polymerase system and evidence for 6α-hydroxylation and Δ6-testosterone formation

Toshifumi AOYAMA, Kenneth KORZEKWA, Kiyoshi NAGATA, James GILLETTE, Harry V. GELBOIN, Frank J. GONZALES

Journal:

Year:

1989

Language:

english

File:

PDF, 854 KB

english, 1989

48

Formation of the Enzyme Complex in Mitochondria Is Required for Function of Trifunctional β-Oxidation Protein

Kenji E. Orii, Toshifumi Aoyama, Masayoshi Souri, Ling Ling Jiang, Koji O. Orii, Shuhei Hayashi, Seiji Yamaguchi, Naomi Kondo, Tadao Orii, Takashi Hashimoto

Journal:

Biochemical and Biophysical Research Communications

Year:

1996

Language:

english

File:

PDF, 75 KB

english, 1996

49

Assignment of the Human Mitochondrial Very-Long-Chain Acyl-CoA Dehydrogenase Gene (LCACD) to 17p13 byin SituHybridization

Toshifumi Aoyama, Keiko Wakui, Yoshimitsu Fukushima, Koji O. Orii, Takashi Hashimoto

Journal:

Year:

1996

Language:

english

File:

PDF, 153 KB

english, 1996

50

Catalytic properties of the human cytochrome P450 2E1 produced by cDNA expression in mammalian cells

Chris J. Patten, Hiroyuki Ishizaki, Toshifumi Aoyama, Maojung Lee, Shu M. Ning, Wen Huang, Frank J. Gonzalez, C.S. Yang

Journal:

Archives of Biochemistry and Biophysics

Year:

1992

Language:

english

File:

PDF, 1.40 MB

english, 1992

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